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While cagrilintide has not yet been approved for therapeutic use, its mechanisms of action have inspired further exploration in research settings, particularly in preclinical and early-phase clinical studies focused on gastrointestinal and metabolic endpoints

Data availability The cryo-EM maps have been deposited in the Electron Microscopy Data Bank (EMDB) under the accession codes EMD-71735 (OCTN2 inward-facing), EMD-71540 (OCTN2 occluded) and EMD-71597 (OCTN2 ipratropium)

Gummin DD, Mowry JB, Beuhler MC, Spyker DA, Brooks DE, Dibert KW, et al

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