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The factors that lead to depletion of glutathione includes natural ageing process, or the external stressors that include chronic exposure to chemical toxins, cadmium exposure, alcohol use, smoking, pollution, strenuous aerobic activities, dietary factors, ultraviolet (UV) radiation exposure, tissue injury as from burns, ischemia, septic shock, surgery, drugs (such as acetaminophen and adriamycin)

Hair loss can have a wide range of underlying causes including androgenetic alopecia, alopecia areata, telogen effluvium, thyroid dysfunction, nutritional deficiencies, and scalp conditions and accurate diagnosis is essential before beginning any treatment

J Anim Sci 88:170180

Rather than approving it, the FDA has prosecuted individuals selling ozone therapy products as medical cures