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3 Ferroptosis in RCC 3.1 Ferroptosis signaling pathway and RCC 3.1.1 HIF-iron metabolism pathway involved in ferroptosis and RCC ccRCC is associated closely with mutations in the VHL gene that lead to the activation of HIF-1 and HIF-2 via a pseudohypoxia mechanism, resulting in the transcription of genes involved in tumor progression (76)

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The GOAT-ghrelin system appears to be a nutrient sensor to signal to the brain that calorie-rich foods are available, leading to optimization of nutrient partitioning and growth signals (46, 47)

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