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A aggregation and tau hyperphosphorylation can disrupt the calcium balance in neurons, leading to mitochondrial calcium overload, increased reactive oxygen species production, reduced ATP generation, and ultimately, neuronal apoptosis or necrosis [76, 77]

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Who benefits the most from B12 injections Clinical evidence shows patients get the clearest benefits from B12 shots when they: Have a confirmed B12 deficiency Have absorption issues that limit oral supplements Are experiencing symptoms directly linked to low B12 levels In these situations, injections are not just helpfultheyre often necessary

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