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Epitalon mechanism is better understood at the enzymatic level (AANAT upregulation, pCREB activation) but the full picture of how it achieves tissue-specific pineal protection remains unclear

Excessive alcohol use activates cytochrome P450 2E1 (CYP2E1), producing harmful reactive oxygen species (ROS) and reducing glutathione, a vital antioxidant

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The city of Mnster, in which a heavy rainfall event in 2014 has led to the loss of lives and destruction of CI (Frerichs et al., 2015), was a cooperation partner for the study by providing data on flood levels in case of an extreme heavy rainfall event for the city area