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Hence, pathways and mechanisms need to be investigated for possible pharmacological intervention

[21] [22] [23] [24] [25] Anemia may present with a number of further common symptoms, [21] [26] including hair thinning and loss, early greying of the hair, mouth ulcers, bleeding gums, [22] angular cheilitis, a look of exhaustion with pale and dehydrated or cracked lips and dark circles around the eyes, as well as brittle nails

These are typical of any subcutaneous injection and generally resolve within a few hours

In severe cases of both Pernicious Anemia and Addisons Disease, surgery may be necessary to remove the affected area of the adrenal gland