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On one hand, moderate HO-1 expression can degrade heme to reduce free iron, inhibit NF-KB activation, and alleviate inflammation and oxidative stress (127)

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3.3 NAC regulates innate immune cells in the bone immune microenvironment to reduce bone resorption In bone tissue engineering, the osteogenic potential of seeding cells including MSCs and precursor cells, is intricately linked to their immune microenvironment