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Since nitrous oxide is commonly used for surgery in the elderly, some experts feel vitamin B 12 deficiency should be ruled out prior to its use or prophylactic vitamin B 12 supplementation implemented before and after exposure to the gas (7, 18)

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Clin Drug Investig 37(3):249-257, 2017

Excessive free reactive Fe (II) can accelerate the generation of deleterious ROS through the Fenton reaction ( The Role of Autophagy In Ferroptosis Autophagy is an evolutionary and conserved important process for the turnover of intracellular substances in eukaryotes ( In addition, ferritinophagy is also related to ferroptosis