NIV is raising $3M in seed financing in two $1.5M tranches to fund study execution, CDMO selection, diagnostics partnership, FDA pre-IND planning, and IP expansion, targeting acquisition or licensing potential within ~36 months
Subsequently a large series of tetrazole derivatives were prepared and examined ( 41 , that is a competitive inhibitor of IRAP and exhibits an IC50 of 540 nM in a recombinant human IRAP assay
A Nature Scientific Reports 2016 study showed GHK-Cu had no cytotoxicity to human keratinocytes at concentrations up to 5,800 M over 72 hours and did NOT induce inflammatory biomarkers (IL-1, IL-8, HSPA1A, FOSL1) unlike other copper compounds, concluding GHK-Cu has a low potential of inducing skin irritation
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