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The possible mechanism of this systemic aldehyde storm is as follows: AA is mainly metabolized in the liver [30], and its metabolite acrolein is detoxified mainly by GSH conjugation catalyzed by glutathione S -transferase or without catalyst and partly by aldehyde dehydrogenases such as ALDH2 [48]

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Our study demonstrated that the anti-ferroptosis effects of metformin are mediated by a modulated microbiota, specifically through the increased presence of Lactobacillus and Lachnospiraceae and the decreased presence of Desulfovibrionaceae