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Animal studies show that it ameliorates depressive-like behavior in CUMS rats, enhances neurotransmitter transmission, and modulates gene expression in astrocytes (Wu Y

Three of the compounds showed a similar protective profile to that of MB with EC50s of 18.99, 4.57, and 1.75 nM for phenothiazine, 2-chlorophenothiazine, and TB, respectively