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Nicotine is arrhythmogenic, because it increases serum catecholamine concentration

The same CDC page also summarizes review findings showing long-term cannabis smoking was associated with worse respiratory symptoms, including reported odds ratios of 1.72.0 for cough and 2.03.0 for wheeze in the evidence it cites, as described on the CDC cannabis and lung health page

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Impairment of Fertility There was no evidence of impairment of fertility in either male or female Sprague-Dawley rats administered varenicline succinate up to 15 mg/kg/day (67 and 36 times, respectively, the MRHD exposure based on AUC at 1 mg twice daily)