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According to research published in Addiction Science & Clinical Practice , daily or near-daily marijuana use (20 or more days per month) is often classified as heavy or chronic use

In some cases pulmonary arterial hypertension (raised blood pressure in the pulmonary artery) develops leading to cor pulmonale (enlargement and strain on the right side of the heart) and, subsequently, edema (accumulation of fluid in the tissues), particularly in the lower legs

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