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During viral infections, IFN-I promotes the clearance of the virus, but it may also cause immunosuppression during chronic infections ( 3 cGAS-STING signaling in the progression of RA 3.1 Elevated levels of cfDNA, cGAS, and STING in RA There was a study that systematically reviewed the level and origin of cfDNA in RA ( In vitro , RA synovial fluid enhanced the production of NETs by neutrophils, as evidenced by the increased levels of DNA in culture supernatants and extracellular DNA on NETs ( Compared with the osteoarthritis (OA) patient-derived FLSs, the levels of cGAS mRNA and cGAS protein were higher in RA-FLSs