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If needles prevent consistency, lower bioavailability with reliable adherence beats higher bioavailability with sporadic use

Meanwhile, studies have designed loaded PEI-SS-IND-MTX-MMP-9 siRNA nanoparticles for RA cartilage damage for the delivery of indindexin (IND), MTX, and MMP-9 siRNA, which significantly downregulated the expression of MMP-9 and various inflammatory factors in Raw-264.7 cells and showed anti-inflammatory activity and reversal of bone destruction in RA mice (291)

However, the process encountered several challenges, including the gap between design and implementation phases, the exclusion of design actors during implementation and significant changes to the proposed designs