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2024;218:82-93.[DOI] 173

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Similarly, the neuroprotective effect of sinomenine on cognitive dysfunction following type 2 diabetes mellitus is achieved through the inhibition of ferroptosis in hippocampal neurons via the classical ferroptosis signaling pathway (epidermal growth factor/nuclear factor erythroid derived 2-related factor 2 (Nrf2)/heme oxygenase 1) and the microbiota-gut-brain axis [101]