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Copper Chelation and Delivery At the most fundamental level, GHK functions as a copper chelator and delivery system - the tripeptide binds Cu with exceptionally high affinity (binding constant approximately 10 M, among the highest known for biological copper chelators), forming a square planar coordination complex where the copper ion is coordinated by the nitrogen atoms of the terminal amino group, the two peptide bonds, and the imidazole nitrogen of histidine
A crucial observation was that DSIPs activating effect on oxidative phosphorylation was selective, primarily increasing V3 without affecting VDNP, and showing no evidence of uncoupling oxidative phosphorylation
Those findings echo earlier results, all obtained within the same health system and facility, including labs contemporaneous with a 2/14/23 CT abdomen/pelvis with triphasic contrast, where venous-phase anatomy in the porta hepatis / gastrohepatic region remains visible across contiguous slices
Distribution The mean volume of distribution (SD) of tesamorelin following a single subcutaneous administration of the 1.28 mg dose of EGRIFTA WR (11.6 mg/vial formulation) was 4.8 1.9 L/kg in healthy subjects
