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[148] found that the dipeptide l-alanyl-l-glutamine administration provided a beneficial ergogenic effect by increasing time to exhaustion following a mild hydration stress, and the effects were linked to an enhanced fluid and electrolyte absorption

Numerous complications may arise, such as rheumatoid vasculitis, permanent joint damage necessitating arthroplasty, and Felty syndrome, which may require splenectomy if left unattended (12, 58)

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Their biological effects are mediated by the glucocorticoid receptor, which acts through both genomic and nongenomic mechanisms to regulate transcriptional signatures and intracellular signaling pathways, respectively