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Dose chart for 30mg vials With 3ml water (10mg/ml concentration) : 30mg vial advantages : Lasts 3-12 weeks depending on dose Economical ($80-120 vs multiple 10mg vials) Flexible for any dose level Standard from most suppliers Supply needed (30mg vials) For complete 20-week protocol : Week 1-4 (2.5mg x 4 doses): 10mg total = 1/3 of vial Week 5-8 (5mg x 4 doses): 20mg total = 2/3 of vial First vial lasts 8 weeks Week 9-12 (7.5mg x 4 doses): 30mg total = 1 vial Week 13-16 (10mg x 4 doses): 40mg total = 1.33 vials Week 17-20 (12.5mg x 4 doses): 50mg total = 1.67 vials Total : 4-5 vials for complete 20-week protocol Cost : $320-600 for complete protocol (at $80-120 per 30mg vial) Most economical option for full protocol

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One of them is the small number of patients, which may lead to false positives, especially as we made no correction for multiple comparisons, given the exploratory nature of this study

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