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This is clinically relevant, as IGF-I is generally less reliable of a biomarker for screening adults above 60 years with GHD and is a better screening and diagnostic biomarker in GHD in subjects with disease onset in childhood or early adulthood (86)

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SS-31 (Elamipretide): The First FDA-Approved Mitochondrial Therapeutic In September 2025, the FDA granted accelerated approval to Forzinity (elamipretide), marking a watershed moment in mitochondrial medicine

Mitochondria are one of the most highly ROS-producing organelles, accounting for almost 90% of cellular ROS