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Chem Pharmaceut Bull 22, 654657

Rarely, the cause of HC is not of primary thyroid origin, but is because of reduced TSH excretion by the pituitary gland (e.g., hypopituitarism) ( Patients presenting with secondary hypothyroidism have been previously submitted to surgery or radiotherapy because of pituitary adenoma, or are affected by pituitary macroadenoma overwhelming TSH-producing pituitary cells

Bouyeh M, Gevorgyan O

Schedule (Once Weekly Injection) Upper limit: 12 mg per week is the highest dose used in the major published clinical trials (Phase 2 obesity, Phase 2 type 2 diabetes, and the Phase 3 TRIUMPH-4 and TRANSCEND-T2D-1 studies)