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A Position Statement of the Forum of International Respiratory Societies"

The ROS produced are converted to peroxynitrite, which has a very strong cytotoxic effect when combined with NO, resulting in direct damage to vascular wall cells and a decrease in the biological activity of NO in vascular endothelial cells and vascular smooth muscle cells [68]

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10.1093/eurpub/ckaa145 [DOI] [PMC free article] [PubMed] [Google Scholar] 95.Kavousi M, Pisinger C, Barthelemy JC, De Smedt D, Koskinas K, Marques-Vidal P, et al