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consequently, ROS underproduction can contribute or even cause some abnormalities resulting in certain diseases [123]

Furthermore, the autophagy receptor FUNDC1 has been shown to induce mitochondrial fragmentation, in addition to its involvement in the essential role of mitophagy (Dirks-Naylor et al., 2014)

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In previous studies, serine and glycine, as well as pyrimidine and purine metabolism alterations have been identified in the serum metabolome of patients with prostate cancer before and after treatment with stereotactic body radiation therapy (SBRT), and combination of intensity-modulated radiation therapy (IMRT) and SBRT [62]