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The potential to counteract these effects has been demonstrated with IL-1 receptor antagonists, which have been shown to improve glucose tolerance and enhance insulin production [571]

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Studies show that MDA levels significantly increase in IL-1- or erastin-induced OA mouse models, while 4-HNE and its protein adducts rise in the synovial fluid and chondrocytes of OA patients, underscoring the critical role of lipid peroxidation in OA pathology (Grigolo et al., 2003

41 In a randomized controlled trial in 162 couples with male infertility undergoing in vitro fertilization, those given 15 mg folic acid per day for three months had better outcomes than those given placebo: 44.1% of couples receiving folic acid were able to conceive and 35.6% had a viable pregnancy detectable on ultrasound at seven weeks of gestation compared with 22.4% and 20.4%, respectively, in those receiving placebo