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l-dopa) can cross the BBB and reach brain tissue via l-type amino acid transporter-1 (LAT-1), the member of solute carrier (SLC) family present at the brain endothelium and diverse brain cells [6]

The combination of all four pathways should theoretically produce earlier onset of appetite suppression, more sustained fullness between meals, increased resting energy expenditure from the glucagon component, and a reduced tendency toward the metabolic adaptation that commonly causes weight loss plateaus on single-agent therapy

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Whole cell GSH abundance (bottom left) and fold change in cell number (log 2 ) of HEK-293T cells expressing a vector control or engineered GshF cDNA treated with indicated BSO concentrations for 5 days (bottom right)