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Several things influence how long a B12 injection lasts for you: Your current B12 levels: the lower you start, the more your body tends to hold on to, which can stretch the effect

After loading, transition to maintenance dosing of 1000 mcg every 1 to 4 weeks depending on response and follow-up testing

IV flushes and analgesic effect: Besides drug mixing, bacteriostatic water (and saline with benzyl alcohol) is often used as an IV flush solution to keep catheters or infusion lines patent

Active patients and those with slow-healing connective tissue injuries are common reasons providers consider it, alongside chronic low-grade inflammation