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However, despite hundreds of publications on the ecological functions and medical uses of cardiac glycosides, the complete biosynthetic pathway has not been identified any plant species

Moreover, GDH1 is dispensable for the proliferation of noncancer cell lines including MRC-5 and HaCaT 19

Emerging evidence implicates programmed necrosis (necroptosis), pyroptosis (gasdermin-D pore formation) and ferroptosis (lipid peroxidation driven by iron accumulation) as additional contributors, implying multiple, drug-specific death executors [72, 79, 84,85,86]

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