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To investigate the impact of ACE2 gene variants on the antidepressant efficacy of SSRIs, a randomized, controlled trial was completed, involving 200 patients with newly diagnosed depression who underwent fluoxetine or sertraline for 6 weeks, along with ACE2 allele genotyping (71)
For instance, rheinDCA accumulates in mitochondria, where it inhibits glycolysis through the PDKPDH axis and disrupts the respiratory chain, thereby inducing oxidative stress, reducing lactate levels, and promoting cell death in CRC models (126)
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