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The major challenge of antibody detection is its inability to differentiate between active and past infections because of the persistence of antibody in serum or other samples after cure, which is demonstrated by the low specificity of serological tests in those individuals from endemic areas and ingesting raw freshwater fish (196, 199)

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The SURMOUNT-1 trial demonstrated that participants on 15 mg tirzepatide lost an average of 20.9% of their body weight over 72 weeks