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B&H Leaf Wrapped aims to provide an option for existing adult smokers who are increasingly seeking lower-priced alternatives, JTI said, and particularly those who smoke the cheapest cigarettes

and nicotine type (tobacco-derived, synthetically derived, or not stated)

Data analysis Sample size re-estimation All analyses were conducted by a senior statistician (MP) and analyst (KDL) who were not involved in data collection and were blinded to allocation

Notably, the whole PBMCs or circulating immune cell subsets from the four healthy and asthmatic smoker/never-smoker groups did not differ in terms of IL-1-producing cell frequencies (Supplementary Fig