The most common side effects of oral silymarin ingestion include:2 Abdominal pain/fullness Bloating Bowel changes Diarrhea Dyspepsia (indigestion) Flatulence Headache Nausea Pruritus (itching) Of note, there's at least one case report of more severe instances of the above, along with sweating, colicky pain, weakness, and collapse, in a 57-year-old woman after taking a milk thistle capsule
SUMMARY In rare cases, taking extremely high doses of certain vitamins may lead to fatal complications
The GSH detection assay is based on the conversion of a luciferin derivative into luciferin in the presence of GSH
Interestingly, a subset of those mitochondrial proteins, namely the cytochrome C oxidase subunit NDUFA4 (NDUFA4), the complex II succinate dehydrogenase (ubiquinone) ironsulfur subunit (SDHB), and cytochrome C oxidase assembly factor 7 (COA7), was found to be enriched in the expanded polyQ ATXN3 samples compared to wild-type, suggesting a stronger interaction [139]