In 2009, a double-blind randomised-controlled trial (RCT) found significant reductions in duration of outbreaks, the number of ulcers and the level of pain in those on B12, 1000 g per day sublingually (form not reported), regardless of B12 level
Sulforaphane is formed by the hydrolysis of glucoraphanin by a plant enzyme called myrosinase, which is inactivated in the stomach of mammals
Kadia T, Garcia-Manero G, Yilmaz M, Dinardo C, Konopleva M, Montalban-Bravo G, Borthakur G, Jabbour E, Jain N, Andreeff M , Short M, Issa G, Ohanian M, Bose P, Daver N, Wang S, Tidwell RS, Estrov Z, Ravandi F, Kantarjian H
Methods: FRTL thyroid cells were treated with IGF-1 or vector control for 24 h