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NPs have been shown to activate intestinal macrophages, which release interleukin-1 (IL-1)a cytokine that influences brain immunityresulting in microglial activation and cognitive decline (Sofield et al., 2024

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The future lies in developing selective modulatorsboth inhibitors and potential activatorstailored to specific diseases and biological contexts, such as hormone-sensitive cancers, neuroinflammatory conditions, and metabolic syndromes

Cholesterol and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) were purchased from Aladdin Biochemical Technology Co