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[] The most important risk factors for severe coronavirus disease-2019 (COVID-19) or death in hospitalized patients are advanced age, sex, hypertension, diabetes, cardiovascular disease, obesity, smoking, and lung disease, especially asthma
Reduced shedding often precedes visible thickening
This model of metabolic feedback is also observed in antiviral immunity, where lactate suppresses type I interferon production by lactylating the key signaling protein MAVS, revealing an unconventional immunosuppressive function [106]
