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The established electrostatic interactions between residues Glu1581 and Gln1355 in the FAT domain and between residues Arg1585 of the FAT domain and Glu2311 of the C-lobe in the fully active state indicate direct communication between the FAT domain and the kinase domain to promote the active state (Fig

Impaired H 2 O 2 transport leads to intracellular H 2 O 2 overload, increasing oxidative stress and exacerbating liver injury during regeneration

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Jaubert MP, Jin Z, Russo C, Schwartz JE, Homma S, Elkind MS, et al