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GIPR agonism could exert beneficial metabolic effects by enhancing glucose-stimulated insulin secretion, increasing postprandial adipose tissue blood flow and triglyceride storage, and by attenuating weight loss-induced bone loss by decreasing bone resorption and increasing osteoblast activity

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The increased availability of short-term external heart assist devices and their development into low profile, high output pumps has shifted the management of cardiogenic shock that is unresponsive to other interventions in the years since these MS-DRGs were created

prolonged overactivation may promote oncogenic pathways or, as seen in clinical trials with bardoxolone methyl, adverse renal outcomes (Pergola et al., 2021)