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Loss of intracellular GSH is likely multifactorial and includes generation of high levels of hydroperoxy-phospholipids (which directly or indirectly oxidize GSH and limit GSSG recycling by reductases) as well as active export of GSSG generated by high GPX4 activity (7, 8, 21)

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Such integrative therapies effectively lower the arsenic burden while preserving renal structure and function

- An increase in glutathione levels in red blood cells following vitamin C supplementation has been observed