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Reports of temporary tiredness or mild headaches when first starting have been reported

This subjective improvement could reflect placebo effect, improved overall nutritional status from paying more attention to diet, natural adaptation to the medication over time, or actual b12 repletion if deficiency existed

Gut-brain and neurological models : Some preclinical literature has examined BPC-157 in nervous-system models, investigating interactions along the gut-brain axis and reporting effects on certain neurotransmitter pathways, including dopaminergic and serotonergic systems in rodents