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In this study, we used a paradigm of BDNF long-term (4 days) incubation to assess in hippocampal neurons in culture, the ability of such a treatment to alter synapses

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Redox-crippled MitoQ is a modified version of the mitochondrial-targeted antioxidant with its redox activity removed, allowing differentiation between effects from its antioxidant properties and other factors ( Adding vincristine to the MitoQ-DPI combination was motivated by its common use in the conventional clinical treatment of high-risk NB (68)

This approach is determined on a case-by-case basis