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Investigators have reported reductions in wrinkle depth, improvements in skin density, and increased dermal fibroblast activity in pre-clinical and limited human-skin studies [2][6]

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Dietary and oral supplementation are the most common ways of achieving adequate B12 levels, but this can be challenging for certain individuals depending on their diet, intestinal health, ability to convert to active forms and other health conditions

Levels naturally decline with age, chronic illness, and prolonged oxidative stress