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As mentioned in the Introduction, both lowered SpO2 and increased body temperature are part of the immune-inflammatory response, predict critical illness and death, and are manifestations of the infectious-immune-inflammatory core of acute COVID-19 [94]

These proteins, in turn, may induce apoptosis of old cells, thereby reducing the old cell burden in tissues

ERGP likely plays a role in regulation of intracellular Ca 2+ levels in pancreatic -cells

Arck et al ., also proposed the free radical theory of greying which described increased apoptosis, reduced oxidative stress protection and increased mitochondrial DNA damage in hair follicles leading to depletion of melanocytes and greying hair 60