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however, this patient has a low level of 1-antitrypsin, so the Pi*MZ phenotype is unlikely

83 , 84 , 85 For example, based on data from a study in Europe and a study in the United States, of people age 6569, the risk of developing dementia by the early to mid80s was 5% to 7% among those with no copies of the e4 form, 15% to 16% among those with one copy, and 31% to 40% among those with two copies