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Increased prolidase activity and oxidative stress in PCOS

It is noteworthy that these potential pathogens are also detectable in healthy individuals, indicating that BRD development is more associated with disruption of host microbial balance than with simple pathogen invasion 103

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Timely intervention with the antioxidant GSH to inhibit high glucose-induced PSC activation and proliferation via blocking the TGF pathway is important for the prophylaxis and treatment of diabetes and may help protect people at risk of T2DM from pancreatic fibrosis and subsequent -cell failure