Our recent study demonstrates the crosstalk between impaired mitochondrial metabolism and dynamics, oxidative stress, inflammation, and ASC malfunction, which suggests that pharmacological modulation of mitochondrial activity might benefit ASC immunomodulatory potential [23]
The functions of other selenoproteins such as GPX6 and SELENOV still remain unclear
FITC anti-human lineage cocktail (47, 48): CD3 (UCHT1, Biolegend), CD14 (HCD14, Biolegend), CD16 (3G8, Biolegend), CD19 (HIB19, Biolegend), CD20 (2H7, Biolegend), CD56 (HCD56, Biolegend) CD235a (HI264, Biolegend), FCRIa (AER-37, Biolegend), CD1a (HI149, Biolegend), CD123 (6H6, Biolegend) and CD5 (L17F12, Biolegend)
Viral and bacterial infections can potentially decrease vitamin C levels because they generate reactive oxygen and nitrogen species through leukocyte activation that lead to oxidation of extracellular vitamin C [47]