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Research has shown that it can significantly decrease the levels of intracellular GSH while simultaneously upregulating the expression of 4-hydroxynonenal and Fe 2+

However, studies in beta-3-AR knockout mice show AOD 9604 still increases energy expenditure and fat oxidation despite the lack of functional beta-3 receptors

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CD-spectra of jr PPO1-wt, the five mutants investigated kinetically Spectra were recorded on a Chirascan Plus spectropolarimeter (Applied Photophysics) purged sufficiently with N 2 before use