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Long-term effect of continuous positive airway pressure therapy on inflammation markers of patients with obstructive sleep apnea syndrome

Both NF-B signaling and mtROS promote NLPR3 inflammasome assembly, a key driver of neuroinflammation that leads to cleavage of precursor cytokines into biologically active pro-inflammatory cytokines, IL-1 and IL-18 (Blevins et al., 2022)

Eprenetapopt/APR-246/PRIMA-1 MET is a small molecule drug which has been proposed to bind to cystine residues in mutant p53, thermodynamically stabilizing it such that both WT conformation and functionality is restored [9]

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