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Confounding variables, such as diet and environmental exposures, complicate comparisons

31 Over time, a third phase of stabilization, erosion and ulceration of the colonic mucosal epithelium may be accompanied by bleeding and the secretion of large amounts of mucus, with relatively stable symptoms that require long-term treatment and management to prevent recurrence

Drug molecules that follow the RO5 have increased chances of reaching the market and have less probability to fail during the clinical trials [26]