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Serum concentrations of human hepatocyte growth factor is a useful indicator for predicting the occurrence of hepatocellular carcinomas in C-viral chronic liver diseases

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Time-course analysis was conducted using two approaches: (i) Hotellings T statistic, combined with a multivariate empirical Bayes method, as implemented in the Timecourse R package [36], and (ii) a composite method based on three polynomial regression models, as implemented in the RolDE R package [37]

(ISBN 978-2-257-20427-1, lire en ligne), p