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In addition, sterol regulatory element-binding proteins (SREBPs), such as SREBP-1, in diabetic kidneys aggravated DN by increasing lipid synthesis [237]

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In the last part of the review we shall consider evidence that bloodbrain barrier mechanisms, while functionally effective in the developing brain, may nonetheless be more susceptible than in the adult to adverse circumstances and that damage to brain barrier mechanisms during development may lead to neurological and neuropsychological dysfunction in later life

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