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In oral cancer, IGFBP-2 promotes the upregulation of matrix metalloproteinase (MMP)2 and MMP9 through the activation of the PI3K/Akt/mTOR signaling pathway, which ultimately leads to the proliferation, migration and invasion of cancer cells (29)

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However, groups switched from WD to LD (WD/LD-V, WD/LD-T) tended to show greater alpha diversity compared to the control groups (WD/WD-V and LD/LD-V), which was not surprising since these animals experienced the most diet transitions with variable nutrient resources during their lifetime